The Molecular and Cellular Basis of Neurodegenerative Diseases Underlying Mechanisms

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common.

This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

• Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features
• Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration
• Details features, advantages and limitations of animal models, as well as prospects for therapeutic development
• Authored by internationally recognized leaders in the field
• Includes illustrations that help clarify and consolidate complex concepts

Table of Contents

1. General Overview
  Michael S. Wolfe
2. Prion Diseases
  Robert C. C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David Harris 
3. Alzheimer’s disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms
  Colin Masters
4. Neurodegeneration and the ordered assembly of Tau 
  Michael Goedert
5. ALS and Other TDP43 Proteinopathies 
  Christopher Shaw and Jorge Gomez-Deza 
6. Parkinson’s Disease and Other Synucleinopathies
  Mark R. Cookson
7. Huntington’s Disease and Other Polyglutamine Disorders 
  Albert R. La Spada and Audrey Dickey 
8. Prion-like propagation in Neurodegenerative Diseases 
  Patrik Brundin, Veerle Baekelandt and Wouter Peelaerts 
9. Neurodegenerative Diseases as Protein Folding Disorders 
  Jack Mathew Webster
10. Heat shock proteins and protein quality control in Alzheimer's disease
  Fred van Leeuwen and Harm H. Kampinga 
11. Neurodegenerative Diseases and Autophagy 
  David C. Rubinsztein
12. Neurodegenerative Diseases and Axonal Transport 
  Larry Goldstein and Utpal Das 
13. Mitochondrial Function and Neurodegenerative Diseases
  Russell Swerdlow
14. Neurodegenerative Diseases and Non-cell autonomous toxicity 
  Azad Bonni
15. Neurodegenerative Diseases and RNA-mediated toxicity 
  Tiffany Todd and Leonard Petrucelli 
16. Neuroinflammation in Age-Related Neurodegenerative Diseases
  Kathryn MacPherson, Maria Elizabeth de Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey 
17. Neurodegenerative Diseases and the Aging Brain 
  Stephen Kenneth Godin, Jinsoo Seo, and Li-Huei Tsai