Systemic Lupus Erythematosus

# Highly illustrated and in full color throughout # Basic science section expanded, allowing the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment # Clinical aspects and new drugs are covered in great detail providing a useful reference to professionals interested in lupus Description Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Lupus is the prototypic autoimmune disease and Systemic Lupus Erythematosus examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Readership Basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists. Residents and fellows in training, as well as primary internists with an interest in the disease and medical libraries. Table of Contents Section I: Basis of Disease Pathogenesis A. Genetics 1 Major histocompatibility complex class II Michelle M. A. Fernando and Timothy J. Vyse 2 Genetic susceptibility and class III complement genes John P. Atkinson, Peter M. Schneider and C. Yung Yu 3 Constitutive genes and lupus Betty P. Tsao and Yun Deng 4 Genetics of lupus in mice Dwight H. Kono and Argyrios N. Theofilopoulos B. Cellular Pathogenesis 5 Tolerance and autoimmunity Shiv Pillai and Kendra N. Taylor 6 Dendritic cells in SLE Gerlinde Obermoser, Karolina Palucka, Hideki Ueno, Jacques Banchereau, and Virginia Pascual 7 T cells and systemic lupus erthematosus Jose C. Crispin and George C. Tsokos 8 B-lymphocyte biology in SLE Mark J. Mamula 9 Polymorhonuclear and endothelial cells Robert Clancy 10 Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE Andras Perl 11 Cell cycle regulation and systemic lupus erythematosus Dimitrios Balomenos 12 The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus Ahmad K. Mashmoushi, Gary S. Gilkeson and Jim C. Oates C. Humoral Pathogenesis 13 Origins of antinuclear antibodies Westley H. Reeves, Yuan Xu, Haoyang Zhuang, Yi Li and Lijun Yang 14 Anti-DNA antibodies: Structure, regulation and pathogenicity Cynthia Aranow, Dun Zhou and Betty Diamond 15 Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis Mary Keogan, Grainne Kearns and Caroline A. Jefferies 16 Antihistone and antispliceosomal antibodies Minoru Satoh, Marvin J. Fritzler, and Edward K. L. Chan 17 Toll-like receptors in SLE Terry K. Means 18 Interferon-alpha in systemic lupus erythematosus Mary K. Crow 19 Immune complexes in systemic lupus erythematosus Mark H. Wener 20 Complement and tissue injury in SLE Chau-Ching Liu and Joseph Ahearn 21 Humoral pathogenesis: Fc receptors in autoimmunity and end-organ damage T. Ernandez and T. N. Mayadas D. Environmental Aspects of Pathogenesis 22 Drug-induced lupus mechanisms Raymond L. Yung and Bruce C. Richardson 23 Gender and age in lupus Robert G. Lahita 24 Roles for infections in systemic lupus erythematosus pathogenesis Evan S. Vista, A. Darise Farris and Judith A. James 25 Systemic lupus erythematosus in domestic animals Michael J. Day E. Mechanisms of Tissue Injury 26 Pathogenesis of lupus nephritis Yong Du and Chandra Mohan 27 Tissue injury and the skin Annegret Kuhn, Markus Bohm and Thomas A. Luger 28 Neuropsychiatric systemic lupus erythematosus: Mechanisms of injury Meggan Mackay, Aziz M. Ulug and Bruce T. Volpe 29 Atherosclerosis and tissue injury in systemic lupus erythematosus Ingrid Avalos and C. Michael Stein Section II: Clinical Aspects of Disease A. Clinical Presentation 30 The clinical presentation of systemic lupus erythematosus Robert G. Lahita 31 Neonatal lupus Jill P. Buyon and Deborah M. Friedman 32 SLE in children Rina Mina and Hermine I. Brunner 33 Drug-induced disease Anne-Barbara Mongey and Evelyn V. Hess 34 Laboratory evaluation of patients with systemic lupus erythematosus Peter H. Schur 35 Pregnancy and reproductive concerns in systemic lupus erythematosus Carl Laskin, Karen Spitzer and Christine A. Clark 36 Epidemiology of systemic lupus erythematosus Catia Duarte, Maura Couto, Luis Ines and Matthew H. Liang 37 Monitoring disease activity Kenneth C. Kalunian and Joan T. Merrill 38 Incomplete lupus erythematosus Johannes C. Nossent and Tom J. G. Swaak 39 Design of clinical trials for SLE Joan T. Merrill, Ken Kalunian and Jill P. Buyon B. Organ Systems 40 The nervous system and lupus John G. Hanly 41 Skin Victoria P. Werth, Cristian Vera-Kellet and Jan P. Dutz 42 Kidney Brad H. Rovin and Isaac E. Stillman 43 Heart Kathleen Macsimowicz-McKinnon and Susan Manzi 44 Vasculitis Barri Fessler and Gary S. Hoffman 45 Lung Aryeh Fischer and Roland M. du Bois 46 Gastrointestinal: Liver Ian R. Mackay 47 Gastrointestinal: Nonhepatic Lloyd Mayer 48 Cellular hematology Seetha U. Monrad and Mariana J. Kaplan 49 Musculoskeletal system: Articular disease, bone metabolism Diane Horowitz, Galina Marder and Richard Furie Section III: Anti-Phospholipid Syndrome A. Pathogenesis 50 Antiphospholipid antibody: Pathogenesis Takao Koike, Tatsuya Atsumi and Olga Amengual 51 Endothelial cell damage and atherosclerosis Joan T. Merrill B. Clinical 52 Laboratory testing for antiphospholipid syndrome Steven Krilis and Yiannia Ioannou 53 Clinical presentation of antiphospholipid syndrome Munther A. Khamashta 54 Pregnancy and antiphospholipid syndrome Kristina Milan and D. Ware Branch 55 Treatment of antiphospholipid syndrome Gerard Espinosa and Richard Cervera Section IV: Treatment 56 Steroids and nonsteroidal anti-inflammatory drugs Olga Dvorkina and Ellen M. Ginzler 57 Antimalarials Nathalie Costedoat-Chalumeau, Gaelle Leroux, Jean-Charles Piette and Zahir Amoura 58 Cytotoxic agents Eva D. Papadimitraki, George Bertsias, George Chamilos and Dimitrios T. Boumpas 59 Biological agents Vasileios C. Kyttaris