Stem Cells From Mechanisms to Technologies

Advances in stem cell biology and biotechnology have sparked hopes that therapies will soon be available for maladies which were considered incurable before. However, realization of the clinical potential of stem cells will require better understanding of stem cell physiology and the development of advanced technologies for their efficient differentiation in medically relevant quantities. Resolving these issues necessitates synergistic approaches from multiple fields. Systems biology can be employed to dissect the mechanisms regulating the genome and proteome of stem cells during self-renewal and commitment. Microfluidic platforms can be used to recreate aspects of the stem cell niche and obtain a better understanding of the interactions among stem cells and with their environment. The milieu of stem cells and their progeny can be shaped with appropriately designed biomaterials for the engineering of tissues to replace, reconstitute or regenerate damaged organs. To that end, enabling bioreactor technologies will be necessary for the generation of large quantities of stem cells and their derivatives in a robust and cost-efficient manner. This book invites world-renowned experts in the above fields to discuss the latest advances in their respective areas and to provide insights on the future challenges and achievements in the area of stem cells.


Contents:
System Biology Lessons for Stem Cells:
Computational Modeling of Biochemical Processes and Cell Differentiation (Max Floettmann, Till Scharp, and Edda Klipp)
Heterogeneity and Flexibility of Stem Cell Fate Decisions — A Conceptual Perspective (Ingmar Glauche and Ingo Roederp)
Comparative Transcriptomics for Global Functional Profiling of Embryonic Stem Cells (Yu Sun and Ming Zhan)
A Common Integrative Nuclear Signaling Module for Stem Cell Development (Michal K Stachowiak, Ewa K Stachowiak, John M Aletta, and Emmanuel S Tzanakakis)
From Mechanisms to Enabling Technologies for Stem Cells:
Generation, Characterization and Propagation of Human Induced Pluripotent Stem Cells (Sheena Abraham, Marion J Riggs, Ena Xiao, Khaled Alsayegh, Venkat Gadepalli, and Raj R Rao)
The Importance of Physiologically Inspired Physicochemical Parameters on Hematopoietic Stem-Cell Maintenance and Lineage-Specific Differentiation in Ex Vivo Cultures (Stephan Lindsey and Eleftherios T Papoutsakis)
Stem Cell Bioprocessing for Regenerative Medicine (Donghui Jing, Abhirath Parikh, and Emmanuel S Tzanakakis)
Engineering Bioactive Scaffold for Stem Cell Vascular Therapy (Abigail C Cuddy, Yu-I Shen, and Sharon Gerecht)
Biofunctionalized Surfaces Controlling Stem Cell Fate Decisions (Leonora Buzanska, Ana Ruiz, and Laura Ceriotti)
Human Umbilical Cord Blood-Derived Cells: Implications in Experimental and Clinical Therapy of CNS Disorders (Barbara Lukomska, Leonora Buzanska, and Krystyna Domanska-Janik)
Triggering Neuronogenesis by Endogenous Brain Stem Cells with DNA Nanoplexes (Ewa K Stachowiak, Indrajit Roy, and Michal K Stachowiak)
Cancer Stem Cells — Targets for Future Cancer Therapies (Andrew Puca, Valentina Malafoglia, and Antonio Giordano)

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