Stem Cell Therapy for Diabetes

This volume reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming.
Full Details

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.
Contents

Part I Beta-Cell Expansion and Regeneration 1. Pancreas and Islet Development George K. Gittes, Krishna Prasadan, and Sidhartha Tulachan 2. Islet and Pancreas Transplantation Davide Mineo, Gaetano Ciancio, George W. Burke, Rodolfo Alejandro, and Camillo Ricordi 3. Cell Cycle Regulation in Human Pancreatic Beta Cells Nathalie Fiaschi-Taesch, George Harb, Esra Karsiloglu, Karen K. Takane, and Andrew F. Stewart 4. Islet Regeneration Xiaobo Xu, Joke D'Hoker, Nico De Leu, Xiangwei Xiao, Yves Heremans, Mark Van De Casteele, and Harry Heimberg 5. Beta-Cell Expansion in Vitro Shimon Efrat Part II Beta Cells from Non-beta Cells 6. What Does It Take to Make a Beta Cell? Gordon C. Weir and Susan Bonner-Weir 7. Generation of Beta Cells from Acinar Cells Luc Baeyens, Ilse Rooman, and Luc Bouwens 8. Generation of Beta Cells from Pancreatic Duct Cells and/or Stem Cells Susan Bonner-Weir and Arun Sharma 9. Adult Cell Reprogramming: Using Nonpancreatic Cell Sources to Generate Surrogate Beta Cells for Treatment of Diabetes Irit Meivar-Levy, Vered Aviv, and Sarah Ferber 10. Embryonic Stem Cells as a Potential Cure for Diabetes Michael A. Bukys and Jan Jensen Part III Tissue Engineering and Immune Protection 11. Functional Tissue Reconstruction with the Use of Biologic Scaffolds Stephen F. Badylak, Jennifer B. Ogilvie, and Thomas W. Gilbert 12. Immunoisolation in Cell Transplantation Riccardo Calafiore and Giuseppe Basta 13. Prevention of Islet Graft Rejection and Recipient Tolerization Eitan M. Akirav and Kevan C. Herold Index

REVIEW-URI