Skeletal Muscle Repair and Regeneration

Skeletal muscle is the most abundant tissue of our body. Apart from its essential role in locomotion, it is also the body’s main store of carbohydrate and protein as well as being one of the principal generators of heat. Its proper maintenance and function are, therefore, essential. A severe acute loss of muscle function is potentially lethal and the debilitating effects of chronic decline in mobility are commonplace experience.

Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. The topics range from correlation of changes in pattern of gene expression with the histological sequence during a regenerative episode to the distinctive insult-specific patterns of structural and functional outcome at the other end of the spectrum. The middle ground – who is doing what in this complex process – constitutes the meat of this sandwich.

Table of contents

Preface.- Myogenesis. The early years.- The origin and genetic regulation of myogenic cells: from the embryo to the adult.- The muscle satellite cell: the story of a cell on the edge!- Non muscle stem cells and muscle regeneration.- Transcriptional cascades in muscle regeneration.- The ins and outs of satellite cell myogenesis: the role of the ruling growth factors.- Relaying the signal during myogenesis: intracellular mediators and targets.- Muscle regeneration in animal models.- Skeletal muscle reconstitution during limb and tail regeneration in amphibians: two contrasting mechanisms.- Muscle fibre regeneration in human skeletal muscle diseases.- Skeletal muscle repair after exercise-induced injury.- Inflammation in skeletal muscle regeneration.- Complexity of extracellular matrix and skeletal muscle regeneration.- Innervation of regenerating muscle.- Boosting muscle regeneration.- Age-dependent changes in skeletal muscle regeneration.

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