Platelets

Highly Commended BMA Medical Book Award 2013: Internal Medicine
Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists
Integrates the entire field of platelet biology, pathophysiology, and clinical medicine
Full color reference comprising 64 chapters, 1400 pages, and 16,000 references
Contributions from 126 world leaders in their fields
New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo

Description

Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

Foreword
A Brief History of Ideas About Platelets in Health and Disease / Barry S. Coller
Part One: Platelet Biology
1. The Evolution of Mammalian Platelets / Jack Levin
2. Megakaryocyte Development and Platelet Formation / Joseph E. Italiano Jr.
3. The regulation of platelet life span / Benjamin T. Kile
4. Platelet Genomics / Willem Ouwehand, Paul F. Bray
5. Platelet MicroRNAs / Patrick Provost
6. The Platelet Proteome / Andrew S. Weyrich
7. Platelet Structure / James G. White
8. The Platelet Cytoskeleton / John H. Hartwig
9. Platelet Receptors / Kenneth J. Clemetson
10. The GPIb-IX-V Complex / Michael C. Berndt
11. GPVI and CLEC-2 / Steve P. Watson, Alice Y. Pollitt, Craig E. Hughes
12. Integrin AlphaIIb Beta3 / Edward F. Plow
13. Protease-activated Receptors / Athan Kuliopulos, Ping Zhang, Lidija Covic
14. The Platelet P2 Receptors / Marco Cattaneo
15. PECAM-1 / Peter J. Newman, Debra Newman
16. Interactions Between Platelets, Leukocytes and the Endothelium / Susan S. Smyth
17. Inhibition of Platelet Function by the Endothelium / Jane E. Freedman
18. Platelet Secretion / Robert Flaumenhaft
19. Signal Transduction During Platelet Plug Formation / Lawrence F. Brass
20. Platelet Thrombus Formation in Flowing Blood / Zaverio M. Ruggeri
21. Interactions Between Platelets and the Coagulation System / Paula B. Tracy
22. Platelet-Derived Microparticles / Rienk Nieuwland
23. The Role of Platelets in Fibrinolysis / Nicola J. Mutch
24. The Role of Platelets in Angiogenesis / Giannoula Lakka Klement, Ela Shai, David Varon
25. Platelet Function in the Newborn / Sara J. Israels
Part Two: Tests of Platelet Function
26. Clinical Tests of Platelet Function / Paul Harrison
27. Platelet Counting / Paul Harrison
28. Platelet Aggregation / Catherine Pauline Hayward, Karen A. Moffat
29. Flow Cytometry / Alan D. Michelson
30. Monitoring of Antiplatelet Therapy / Paul A. Gurbel, Udaya S. Tantry
31. Real Time In Vivo Imaging of Platelets During Thrombus Formation / Bruce Furie, Barbara Furie
Part Three: The Role of Platelets in Disease
32. Atherothrombosis and Coronary Artery Disease / Meinrad Gawaz
33. Central Nervous System Ischemia / Gregory J. del Zoppo
34. Peripheral Vascular Disease / Michael Sobel
35. Diabetes Mellitus / Giovanni Davi
36. Inflammation / Guy Zimmerman
37. Antimicrobial Host Defense / Michael R. Yeaman, Arnold Bayer
38. Tumor Growth and Metastasis / Jerry Ware
Part Four: Disorders of Platelet Number and Function
39. The Clinical Approach to Disorders of Platelet Number and Function / Alan D. Michelson
40. Immune Thrombocytopenia (ITP) / James B. Bussel, Bethan Psaila
41. Drug-induced Thrombocytopenia / Richard H. Aster
42. Heparin-induced Thrombocytopenia / Andreas Greinacher, Theodore Warkentin, Beng H. Chong
43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome / Han-Mou Tsai
44. Thrombocytopenia in Pregnancy / Keith R. McCrae
45. Thrombocytopenia in the Newborn / Irene A.G. Roberts
46. Alloimmune Thrombocytopenia / Cecile Kaplan, Heyu Ni, John Freedman
47. Inherited Thrombocytopenias / Mortimer Poncz, Michele P. Lambert and Ravichandran Mohan
48. Pseudothrombocytopenia / Nicola Bizzaro
49. Thrombocytosis and Essential Thrombocythemia / Ayalew Tefferi
50. Congenital Disorders of Platelet Function / Marco Cattaneo
51. Acquired Disorders of Platelet Function / A. Koneti Rao
52. Cardiopulmonary Bypass / Brian Richard Smith, Henry M. Rinder, Christine S. Rinder
Part Five: Antiplatelet Therapy
53. Aspirin / Carlo Patrono
54. ADP Receptor Antagonists / Marco Cattaneo
55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists / Anthony A. Bavry
56. Dipyridamole / Wolfgang G. Eisert
57. Cilostazol / Yasuo Ikeda, Toshiki Sudo
58. Novel Antiplatelet Therapies / Deepak L. Bhatt
Part Six: Therapy to Increase Platelet Numbers and/or Function
59. Thrombopoietin Mimetics / David J. Kuter
60. Desmopressin / Pier Mannuccio Mannucci
61. Factor VIIa / Man-Chiu Poon
62. Platelet Transfusion Medicine / Peter L. Perrotta, Jeremy Parsons, Henry M. Rinder, Edward L. Snyder
63. Making Platelets Ex Vivo / Mortimer Poncz, Spencer Sullivan, Michele P. Lambert
64. Gene Therapy for Platelet Disorders / David A. Wilcox

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