Plant Extracts in Neurodegenerative Diseases

Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease.

• Discusses the therapeutic efficacy of plant extracts and their lead bioactive compounds to treat neurodegenerative disease
• Describes protective mechanisms, pros and cons, and future perspectives
• Contains individual diseases in each chapter, including Alzheimer’s, Parkinson’s, Huntington’s, motor neuron disease, spinocerebellar ataxia, prion disease, SMA and ALS

Table of Contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• About the author
• Acknowledgments
• Chapter 1: Effect of plant extracts against Alzheimer’s disease
• Abstract
• Introduction
• Plant extracts
• Polyphenols
• Flavonoids
• Genistein
• Icariside
• Onjisaponin
• Asarones
• Liquiritin
• Tanshinone IIA and cryptotanshinone
• Ginsenoside Rg1
• n-Butylidenephthalide
• Green nanotechnology
• Conclusions and future perspectives
• References
• Chapter 2: Potential plant extracts in the treatment of Parkinson’s disease
• Abstract
• Introduction
• α-Synuclein
• Plant extracts
• Pharmacological chaperones combat Parkinson’s disease
• Phytochemicals
• Baicalein
• Curcumin
• Nanotechnology
• Scutellaria pinnatifida (S. pinnatifida)
• Hypericum perforatum
• Mentha × piperita (peppermint)
• Cyanobacteria spirulina
• Omega-3 fatty acids
• Conclusions and future perspectives
• References
• Chapter 3: Panoply of plant extracts in the treatment of prion diseases
• Abstract
• Introduction
• Plants and prions
• Metal dyshomeostasis
• Plants
• Polyphenols
• Resveratrol
• Curcumin
• Polyphenolic metal chelators
• Mediterranean diet
• Lichens
• Conclusions and future perspectives
• References
• Chapter 4: Efficacy of plant extracts against Friedreich’s ataxia
• Abstract
• Introduction
• Frataxin
• Iron accumulation
• Iron dyshomeostasis in Friedreich’s ataxia
• Plant extracts
• Coenzyme Q10 and idebenone
• Nuclear factor erythroid 2-related factor
• Resveratrol
• Antioxidants
• Conclusions and future perspectives
• References
• Further reading
• Chapter 5: Plant extracts ameliorate Huntington’s disease symptoms
• Abstract
• Introduction
• Pathology
• Antioxidants
• Oxidative stress in Huntington’s disease
• Plant extracts
• Clinical trials
• Cleistocalyx nervosum var. paniala
• Guarana
• Protective efficacy of guarana against neurodegenerative diseases
• Conclusions and future perspectives
• References
• Chapter 6: Phytochemicals and their potential protective effects against spinocerebellar ataxia
• Abstract
• Introduction
• Dendrite
• Plant extracts
• Ubiquitin-proteasome system and mechanism of action
• Antioxidant activity
• Ginkgo biloba
• Bacopa monnieri
• Chionanthus retusus Lindl. et Paxton (C. retusus)
• Azadiradione
• Conclusions and future perspectives
• References
• Chapter 7: Multifarious plant compounds and their protective efficacy in the treatment of spinal muscular atrophy
• Abstract
• Introduction
• Nusinersen therapy
• Plant extracts
• Kiwi fruit
• RNA-targeted therapy
• Conclusions and future perspectives
• References
• Chapter 8: Improvement of amyotrophic lateral sclerosis symptoms using plant extracts
• Abstract
• Introduction
• DNA damage
• Plant extracts
• Clinical trials
• Mecasin
• Ashwagandha
• Withaferin A
• Drawbacks
• Polyphenols
• Resveratrol
• Curcumin
• Conclusions and future perspectives
• References
• Further reading
• Chapter 9: Neuroprotective role of curcumin in amyotrophic lateral sclerosis
• Abstract
• Introduction
• Oxidative stress
• Therapy
• Curcumin
• Dimethoxy curcumin
• Curcumin against TDP-43
• Use of adjuvants
• Nanotechnology
• Nanocurcumin in the treatment of ALS
• Conclusions and future perspectives
• References
• Index

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