Parkinson's Disease and Related Disorders Part I and Part II; Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

The two volumes on Parkinson’s disease in the Handbook of Clinical Neurology (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, National Institutes of Health, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) cover a group of disorders that constitute the commonest of neurodegenerative diseases and one that is assuming ever greater importance with the ageing of the population in developed countries. The coverage reflects the dramatic advances in understanding of the biochemical background of parkinsonism and the resulting developments in the pharmacological management of the disease. These volumes give a comprehensive account of the subject for both clinical neurologists and those researching in the neurosciences. Part I covers the scientific background, general aspects of Parkinson’s disease, clinical aspects and etiology. Part II covers the medical and surgical treatment of Parkinson’s disease, complications of therapy and the other parkinsonian syndromes. .


Features

# Part I of a two volume set on Parkinson's Disease in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
# International list of contributors including the leading workers in the field.
# Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of Parkinson's Disease and on patient care.
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Contents

Section 1: Scientific foundation
Anatomy and physiology of the basal ganglia: relevance to parkinson’s disease and related disorders. Functional neurochemistry of the basal ganglia. Dopamine receptor pharmacology.
Section 2: General aspects of Parkinson's disease
History of Parkinson’s disease. Epidemiology of Parkinson’s disease. Neurochemistry of the basal ganglia in Parkinson’s disease. The neuropathology of parkinsonism. Imaging Parkinson’s disease. Parkinson’s disease: animal models.
Section 3: Clinical aspects
Scales to measure parkinsonism. Motor symptoms in Parkinson’s disease. Autonomic dysfunction in Parkinson’s disease. Sleep in Parkinson syndromes. Sensory symptoms in Parkinson’s disease. Speech disorders in Parkinson’s disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment. Clinical features, pathophysiology and treatment of dementia associated with Parkinson’s disease. Disorders of mood and affect in Parkinson’s disease. Neurobehavioral disorders in Parkinson’s disease. Early detection of Parkinson’s disease.
Section 4: Etiology
Mitochondria in the etiology of Parkinson’s disease. Iron as a trigger of neurodegeneration in Parkinson’s disease. Oxidative stress and Parkinson’s disease. Neurotrophic factors and Parkinson’s disease. Neuroinflammation and Parkinson’s disease. Excitotoxicity. Protein handling dysfunction in Parkinson’s disease. Programmed cell death in Parkinson’s disease.

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