Neurobiology of Depression Road to Novel Therapeutics

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD.

Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.

• Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations
• Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics
• Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Table of Contents

1. The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoC
   Elizabeth D. Ballard, Ioline D. Henter and Carlos A. Zarate, Jr.
   2. The Role of Environmental and Psychosocial Factors in Depression
   Gordon Parker
   3. Gene-Environment Interactions and Epigenetic Mechanisms in Depression
   Magdalene C. Jawahar, Catherine G. Toben and Bernhard T. Baune
   4. Pathophysiology of Cognitive Impairment in Depression
   Christopher R. Bowie, Melissa Milanovic and Tanya Tran
   5. Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics
   Theodore P. Beauchaine, Daniel N. Klein, Erin Knapton and Aimee Zisner
   6. The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications
   Minal Jaggar, Sashaina E. Fanibunda, Shreya Ghosh, Ronald S. Duman and Vidita A. Vaidya
   8. Neuro-Immune Interactions in Depression: Mechanisms and Translational Implications
   Helena M. Abelaira, Ritele H. Silva, Anelise S. Carlessi, João Quevedo and Gislaine Z. Réus
   9. The Hypothalamic-Pituitary-Adrenal Axis in Depression: Molecular Regulation, Pathophysiological Role, and Translational Implications
   Theo Rein, Oliver Ambrée, Gabriel R. Fries, Virginie Rappeneau, Ulrike Schmidt and Chadi Touma
   10. Intracellular Signaling Pathways Implicated in the Pathophysiology of Depression
   Gislaine Z. Réus, Jaqueline S. Generoso, Ana Lúcia S. Rodrigues and João Quevedo
   11. The Long-Lasting Neurobiological Scars of Early-Life Stress: Implications for the Neurobiology of Depression
   Mousa Botros, Gabrielle Hodgins and Charles B. Nemeroff
   12. Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
   Ming-Hu Han, Scott J. Russo and Eric J. Nestler
   13. More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of Depression
   Jane A. Foster
   14. Optogenetics: Illuminating the Neural Circuits of Depression
   Muir J. and Bagot R. C.
   15. Mitochondrial Dysfunction and Oxidative Stress: Relevance to the Pathophysiology and Treatment of Depression
   Adrian L. Lopresti
   16. Obesity and Depression: Shared Pathophysiology and Translational Implications
   Lison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon and Lucile Capuron
   17. Depression and Cardiovascular Risk: Epidemiology, Mechanisms, and Implications
   Jessica Hatch and Benjamin I. Goldstein
   18. Poststroke Depression: Pathophysiology and Treatment Strategies
   Yun-Ju Lai and Louise D. McCullough
   19. Is Depression Associated With Accelerated Aging? Mechanisms and Implications
   Daniel Lindqvist, Naomi M. Simon and Owen M. Wolkowitz
   20. Relationship Between Complicated Grief and Depression: Relevance, Etiological Mechanisms, and Implications
   Nicole J. LeBlanc, Naomi M. Simon, Charles F. Reynolds, III, M. Katherine Shear, Natalia Skritskaya and Sidney Zisook
   21. A Neural Circuit-Based Model for Depression Anchored in a Synthesis
   of Insights From Functional Neuroimaging
   Andrea N. Goldstein-Piekarski and Leanne M. Williams
   22. Could Depression be Preventable? Evidence and Perspectives
   Scott B. Patten
   23. Treating Depression in the Era of Precision Medicine: Challenges and Perspectives
   Michael Musker and Ma-Li Wong
   24. Neurobiological Aspects of Functional Recovery in Major Depressive Disorder
   Trisha Chakrabarty, David Sarfati and Raymond W. Lam
   25. Diet and Depression: From Epidemiology to Novel Therapeutics
   Wolfgang Marx, Erin Hoare and Felice Jacka
   26. Physical Activity and Exercise as a Treatment of Depression: Evidence and Neurobiological Mechanism
   Brendon Stubbs and Felipe Schuch
   27. Antidepressants and Suicidality—
   Controversies and Possible Mechanisms
   Josef Witt-Doerring and Sanjay Mathew
   28. Altered GABAergic Function, Cortical Microcircuitry, and Information Processing in Depression
   Dwight F. Newton, Corey Fee, Yuliya S. Nikolova and Etienne Sibille
   29. Biomarker-Based Treatment Selection: A Precision Medicine Approach for Depression
   Jennifer L. Furman and Madhukar H. Trivedi
   30. Implications of Pharmacogenomics in Depression Pathophysiology and Treatment
   Forbes M. P., Jaksa P., Eyre H. A. and Bousman C.
   31. Novel Neuromodulatory Approaches for Depression: Neurobiological Mechanisms
   Lucia Bulubas, Eva Mezger, Daniel Keeser, Frank Padberg and Andre R. Brunoni
   32. Electroconvulsive Therapy for Depression: Neurobiological Mechanisms
   Peter Mulders, Stevie Jaarsveld, Indira Tendolkar and Philip van Eijndhoven
   33. Deep Brain Stimulation: Mechanisms Underpinning Antidepressant Effects
   Sonia Torres-Sanchez, Laura Perez-Caballero and Esther Berrocoso
   34. Novel Therapeutic Targets for Major Depressive Disorder
   Max A. Lazar and Roger S. McIntyre
   35. The Search for Rapid Acting Antidepressants: Research Synthesis and Perspectives
   Gerard Sanacora, Brandon M. Kitay and Samuel T. Wilkinson
   36. Pediatric Depression
   Frances Rice and Naomi Warne
   37. Depression in Women
   Molly M. Hyer and Gretchen N. Neigh
   38. Advances in the Neurobiology of Late-Life Depression
   Breno Satler Diniz and Antonio Lucio Teixeira