Human Aging From Cellular Mechanisms to Therapeutic Strategies

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging.

The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.

Key Features

• Concentrates on different processes, e. g., oxidative stress, cellular senescence and Inflammaging
• Offers the ability to access cross-sectional knowledge more easily
• Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Readership

Graduate and PhD students as well as researchers interested or working in various aspects of aging. Clinical researchers and medical professionals in biogerontology and geriatrics

Table of Contents

1. Aging and longevity: An evolutionary approach
   2. Demographic aspects of aging
   3. Pathobiology of aging: An introduction to age-related diseases
   4. Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
   5. The role of inflammaging in the development of chronic diseases of older people
   6. A new perspective on ROS in aging with an integrated view of the gut microbiota
   7. Aging of immune system
   8. Vaccination in old age: Challenges and promises
   9. Resilience signaling and hormesis in brain health and disease
   10. Different components of frailty in the aging subjects—The role of sarcopenia
   11. Hormones in aging
   12. Chronobiology and chrononutrition: Relevance for aging
   13. Nutraceutical approach to age-related diseases—The clinical evidence on cognitive decline
   14. Ways to become old: Role of lifestyle in modulation of the hallmarks of aging
   15. Nutritional biomarkers in aging research
   16. The role of cytomegalovirus in organismal and immune aging
   17. Ethics of aging
   18. Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?

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