Hayes' Principles and Methods of Toxicology

Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. 

Key Features:

• The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals.
• Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered.
• All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences
• New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. 　

The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). 

This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

SECTION I　　　　Principles of Toxicology

Chapter 1　　　　History, Understanding and a Possible Future of Toxicology. Harming and Helping through Time.

Richard W. Lane with revisions and a new section by Anthony D. Dayan 

Chapter 2　　　　Use of Toxicology in the Regulatory Process 

Robyn L. Prueitt, Barbara D. Beck, and Edward J. Calabrese

Chapter 3　　　　The Dose–Response: A Fundamental Concept in Toxicology 

Edward J. Calabrese

Chapter 4　　　　Metabolism: A Determinant of Toxicity 

Tao Wang and Richard Zang

Chapter 5　　　　Toxicokinetics 

Leanne L. Bedard 

Chapter 6　　　　Physiologically Based Pharmacokinetic and Toxicokinetic Models 

Harvey J. Clewell III, Rebecca A. Clewell, and Melvin E. Andersen

Chapter 7　　　　Toxicopanomics: Applications of Genomics, Transcriptomics,
Proteomics, Metabolomics and Lipidomics in Predictive Mechanistic Toxicology 

Mohamed-Amin Choukrallah, Marja Talikka, Stephanie Boue, Philippe Alexandre Guy, Aditya Reddy Kolli, Sandro Steiner, David Bovard, Diego Marescotti, Oksana Lavrynenko, Catherine Nury, James N. Battey, Bjorn Titz, Ulrike Kogel, Alain Sewer, Nicolas Sierro, Florian Martin, Nikolai V. Ivanov, Manuel C. Peitsch, and Julia Hoeng

Chapter 8　　　　 Toxicologic Assessment of Pharmaceutical, Medical Device and Biotechnology Products

Michael A. Dorato, Caitlin J. Murphy, J. Scott Daniels, Erin M. Quist, and C. Steven Godin

Chapter 9　　　　Statistics and Experimental Design for Toxicologists 

Shayne C. Gad

Chapter 10　　The Practice of Exposure Assessment 

Dennis J. Paustenbach, Amy K. Madl, and Andrey Massarsky

Chapter 11　　Epidemiology for Toxicologists 

Geary W. Olsen, Robert R. Roy, Sarah E. Kleinschmidt, and Ralph R. Cook

Chapter 12　　Pathology Principles and Practices for Toxicity Studies

Brad Bolon, Tara Arndt, Adam Aulbach, and Kenneth A. Schafer

Chapter 13　　Chemical Toxicology Information Resources

Stephanie Holmgren, Jacqueline Patterson, Kristina Thayer, Philip Wexler, and Antony J. Williams

SECTION II　　　　Agents

Chapter 14　　Food Safety and Foodborne Toxicants 

Fleur De Mooij, Yu Janet Zang, Amy L. Roe, and Angelika Tritscher

Chapter 15　　Plant and Animal Toxins 

Kevin D. Welch, Glenn F. King, Julian White, Leanne A. Pearson, Brett A. Neilan, and Daniel Cook

Chapter 16　　Safety Assessment of Cosmetics and Personal Care Products 

Christina Hickey, Siti Amelia Juraimi, Lauren Hutchison, Anne Marie Api, and Benjamin P.C. Smith

Chapter 17　　Solvents and Industrial Hygiene 

John E. Snawder

Chapter 18　　Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 

James Bus 

Chapter 19　　Metals 

Paul B. Tchounwou, Joseph R. Landolph, Jr., and Janis E. Hulla 

Chapter 20　　Radiation Toxicity

Roger O. McClellan

SECTION III　　　　Methods

Chapter 21　　The Humane Care and Use of Laboratory Animals in Toxicology Research 

Michael J. Caruso, Tyler C. Plachta, Christopher N. Papagiannis, Zac Lloyd, Dale M. Cooper, and David G. Serota

Chapter 22　 Novel Approaches and Alternative Models. Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies 

Nicole Kleinstreuer and David Allen

Chapter 23　　Modern Instrumental Methods for Studying Mechanisms of Toxicology

W.M. Coleman, III, Serban C. Moldoveanu, Mehdi Ashraf-Khorassini, and Francis L. Martin

Chapter 24　　Acute Toxicity and Eye Irritancy 

Saura C. Sahu and A. Wallace Hayes

Chapter 25　　Short-Term, Subchronic, and Chronic Toxicology Studies

Daniel T. Wilson, Jerry F. Hardisty, Torrie A. Crabbs, and Shannon M. Wallace

Chapter 26　　Genetic and Epigenetic Toxicology 

Leslie Recio and Tetyana Kobets 

Chapter 27　　Carcinogenicity Bioassays and Related Assays; Human Relevance 

Gary M. Williams, Tetyana Kobets, Michael J. Iatropoulos, Thomas Nolte, and Esther Vock 

Chapter 28　　Assessment of Behavioral Toxicity 

Deborah A. Cory-Slechta and Marissa Sobolewski 

SECTION IV　　　　Organ- and System-Specific Toxicology

Chapter 29　　Dermatotoxicology 

Benjamin B. Hayes and Howard J. Maibach

Chapter 30　 Inhalation Toxicology 

John J. Godleski, Sandra A. McDonald, and Lester Kobzik

Chapter 31　　Gastrointestinal Toxicology 

Peter Pressman, Roger Clemens, and Robert W. Kapp, Jr.

Chapter 32　　Hepatotoxicology 

Maksat Babayev, Luma Melo, and James Klaunig

Chapter 33　　Principles and Methods for Renal Toxicology 

Jennifer G. Schnellmann and Rick G. Schnellmann 

Chapter 34　　Cardiovascular Toxicology Methods 

Barry Bleske and Matthew J. Campen 

Chapter 35　　Neurotoxicology 

Anke M. Tukker, Aaron B. Bowman, Lucio G. Costa, and Michael Aschner

Chapter 36　　Toxicology of the Endocrine System

Carr J. Smith, Thomas A. Perfetti, and Judy A. King 

Chapter 37　　Assessment of Male Reproductive Toxicity 

Natasha R. Catlin, Jon C. Cook, and Gregg D. Cappon 

Chapter 38　　Female Reproductive and Developmental Toxicology 

Stephen B. Harris, Kary E. Thompson, Pragati S. Coder, Eve Mylchreest, Amy Lavin Williams, and John M. DeSesso

Chapter 39　　Immunotoxicology. The Immune System Response to Toxic Insult

Florence G. Burleson, Stefanie C.M. Burleson, Gary R. Burleson, and Victor J. Johnson

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