Handbook of Clinical Nanomedicine, Two-Volume Set

Features

• Examines the entire "product wheel" from creation of nanomedical products to final market introduction in a stand-alone, easily accessible volume
• Serves as an essential reference for the novice and expert alike in fields such as medicine, law, biotechnology, pharmaceutical sciences, engineering, biomedicine, policy, future studies, ethics, intellectual property law, licensing, and toxicology
• Addresses critical topics such as ethics, safety and toxicity, environmental health, nanoeconomics, business strategy, licensing, intellectual property, FDA law, EPA law, and governmental policy issues

Summary

The enormous advances in nanomedicine in the past decade have necessitated a growing need for an authoritative and comprehensive reference source that can be relied upon by scientists, clinicians, students, and industry and policy makers alike. The Handbook of Clinical Nanomedicine: From Bench to Bedside is designed to offer a global perspective on the wonders of nanomedicine.

The handbook aims to provide a broad survey of various interconnected topics pertaining to nanomedicine. It is intended to be a stand-alone, easily accessible volume that examines the entire "product wheel" from creation of nanomedical products to final market introduction, all accomplished in a user-friendly format. Specifically, everything from bio-nanomaterials and nanodevices from the R&D stage to patent protection, clinical regulatory aspects, and eventual commercialization is encompassed in this book. In addition to highlighting cutting-edge technologies, the book addresses critical topics such as ethics, safety and toxicity, environmental health, nanoeconomics, business strategy, licensing, intellectual property, FDA law, EPA law, and governmental policy issues. With contributions from international experts, the diverse team of editors has compiled a book that provides a unified perspective to these varied topics. While many books focus on nanomedicine, nanotechnology, or nanoscience, none provide the medical applications of nanotechnology with both a clinical and business angle. Furthermore, most of the currently available books on the market fail to highlight the truly global nature of nanomedicine.

Table of Contents

Volume 1

Section I – Introduction and Beginnings

Science at the nanoscale: introduction and historical perspective; Shong, Haur, and Wee

Nanomedicine: dynamic integration of nanotechnology with biomedical science; Lee, Solanki, Kim, and Jung

A small introduction to the world of nanomedicine; Ellis-Behnke

Top ten recent nanomedical advances; Swan

The coming era of nanomedicine; Allhoff

What’s in a name? Defining "nano" in the context of drug delivery; Bawa

Section II – Nanoparticles, Nanodevices and Imaging

Properties of nanoparticulate materials; Tsuzuki

Solid drug nanoparticles: methods for production and pharmacokinetic benefits;Owen and Rannard

Design and development of approved nanopharmaceutical products; Mansour, Park, and Bawa

Nanonsizing approaches in drug delivery; Chavhan, Petkar, and Sawant

Multilayered nanoparticles for personalized medicine: translation into clinical markets; Movia, Poland, Tran, Volkov, and Prina-Mello

Nanomaterials for pharmaceutical applications; Loretz, Jain, Dandekar, Thiele, Hiroe, Mostaghaci, Lian, and Lehr

Polysaccharides as nanomaterials for therapeutics; Mizrahy and Peer

Lipid-like delivery materials for efficient siRNA delivery; Dahlman, Langer, and Goldberg

Applications of nanoparticles in medical imaging; Dearling and Packard

Nanoimaging for nanomedicine; Lyubchenko, Zhang, Krasnoslobodtsev, and Rochet

Nanoparticles for multi-modality diagnostic imaging and drug delivery; Lockhart and Ho

Magnetic nanoparticles in magnetic resonance imaging: a translational push toward theranostics; Ortega, Yankeelov, and Giorgio

First-in-human molecular targeting and cancer imaging using ultrasmall dual-modality C-dots; Bradbury and Wiesner

Atomic Force Microscopy for nanomedicine; Sharma and Gimzewski

Atomic Force Microscopy imaging and probing of amyloid nanoaggregates;Lyubchenko and Shlyakhtenko

Image-based high-content analysis, stem cells and nanomedicines: a novel strategy for drug discovery; Solomesky, Adalist, and Weil

Viral nanoparticles: tools for materials science and biomedicine; Steinmetz and Manchester

Bacterial secretion systems: nanomachines for infection and genetic diversity; Shala, Ferarro, and Audette

The vascular cartographic scanning nanodevice; Boehm

Advancements in ophthalmic glucose nanosensors for diabetes management;Domschke

Section III – Clinical Applications of Nanotherapeutics

Nanoscale therapeutics: introductory overview of key issues; Bawa, Szebeni, Bawa, and Mehra

Copaxone® in the era of biosimilars and nanosimilars; Conner, Bawa, Nicholas, and Weinstein

Doxil®: the first FDA-approved nano-drug; Barenholz

Nanotechnology and the skin barrier: topical and transdermal nanocarrier-based delivery; Labouta and Schneider

Application of nanotechnology in non-invasive topical gene therapy; Elsabahy, Jimena Loureiro, and Foldvari

Nanocarriers in the therapy of inflammatory disease; Lamprecht

Nanoparticles for targeting T cells in allergy and inflammatory airway conditions;Bear, Carpin, Cruz, Drezek, and Fostera

Nanomedicine for acute lung injury/acute respiratory distress syndrome: a shifting paradigm?; Sadikot and Rubinstein

Nanoviricides: targeted anti-viral nanomaterials; Barton, Tatake, and Diwan

Nanotechnology in tissue engineering for orthopaedics; Hamming and Hamming

Applications of nanomaterials in dentistry; Jurczyk and Jurczyk

Biomimetic applications in regenerative medicine: scaffolds, transplantation modules, tissue homing devices, and stem cells; Green and Ben-Nissan

Potential applications of nanotechnology in the nutraceutical sector; Wang and Zhang

Designing nanocarriers for the effective treatment of cardiovascular diseases; Vaidya and Vyas

Carbon nanotubes as substrates for neuronal growth; Ménard-Moyon

Polymeric nanoparticles for cancer therapeutics; Verma, Rosen, Meerasa, Yoffe, and Gu

Nanotechnology for radiation oncology; Sridhar, Berbeco, Cormack, and Makrigiorgos

Gold against cancer; Comenge, Romero, Conill, and Puntes

Solid lipid nanoparticles and nanostructured lipid carriers for cancer therapy; Uner

Nanomedicine targeted to aberrant cancer signalling and epigenetics; Ratnakumari, Chandran, Malarvizhi, Nair, and Koyakutty

Biodegradable nanoparticle-based antiretroviral therapy across the blood brain barrier; Mahajan, Yu, Aalinkeel, Reynolds, Nair, Mammen, Ignatowski, Cheng, and Schwartz

HIV-specific immunotherapy with synthetic pathogen-like nanoparticles; Lorincz and Lisziewicz

Nanotechnology toward advancing personalized medicine; Sakamoto, Godin, Hu, Blanco, van de Ven, Vellaichamy, Murphy, Francesca, Schuenemeyer, Given, Meyn, and Ferrari

Nanotechnology-based systems for microbicide development; Nunes, Sousa, Sarmento, and das Neves

Nanotechnology based solutions to combat the emerging threat of superbugs: current scenario and future prospects; Kalarickal and Mahajan

Nanolithography and biochips’ role in viral detection; Tsarfati-BarAd and Gheber

Volume 2

Section I – Law, Business and Commercialization

An intellectual property primer for nanomedical researchers and engineers; Reese

Strategic intellectual property management: building IP portfolios; Langer

Extending patent term for nanomedical inventions: a nexus between the FDA and the patent system; Hopkins and Zytcer

When patented technologies get put to experimental use: practical considerations for nanotech R&D; Polk and Fayerberg

Critical legal and business strategies for resolving patent disputes over nanoscale drug delivery systems; Harris, Hermann, Bawa, Clevland, and O'Neil

What the Supreme Court’s Myriad decision means for nanotechnology patents;Baluch, Maebius, and Wegner

Managing the expense of patent litigation in nanotechnology; Vare

Technology transfer: an overview; Goldstein

Licensing issues in nanotechnology; Brougher

Commercializing your intellectual property: steps to take and pitfalls to avoid; Dahlin and Pomianek

Overcoming nanotechnology commercialisation challenges: case studies of nanotechnology ventures; Maine

The commercialisation of nanotechnology: the five critical success factors to a nanotech-enabled whole product; Belcher, Marshall, Edwards, and Martina

Overcoming the odds: how to incubate fledging bioscience companies; Breedlove

Market opportunity for molecular diagnostics in personalized cancer therapy; Piros, Petak, Erdos, Hautman, and Lisziewicz

Nanotechnology implications for labor; Invernizzi and Foladori

Insurance market perception of nanotechnology and nanomaterials risks; Baublyte, Mullins, Murphy, and Tofail

Section II – Regulatory Issues and Nanogovernance

FDA and nanotech: baby steps lead to regulatory uncertainty; Bawa

EU regulation of nanobiotechnology; Quinn

Regulating nanomedicine; Fischer

Nanomedicines: addressing the scientific and regulatory gap; Tinkle, McNeil, Muhlebach, Bawa, Borchard, Barenholz, Tamarkin, and Desai

Regulation of combination products in the United States; Weiner and Nguyen

Regulation of combination products in the European Union; Jamieson and Baker

Brief overview of current developments in nanotechnology EHS regulation in the U. S;Voorhees

EPA targets nanotechnology: hi-ho, nanosilver, away?; Wallace and Schenck

Graphene: regulatory considerations for the "wonder material"; Kaplan and Woloschyn

The enduring embrace: the regulatory ancien régime and governance of nanomaterials in the U. S.; Bosso

Section III – Health, Safety, Risk and Biological Interactions

Safety of engineered nanomaterials and occupational health and safety issues for commercial-scale production; Wright and Jackson

Engineered nanoparticle release, exposure pathway and dose, measures and measuring techniques for nanoparticle exposure in air; Fissan and Horn

Managing environmental and health risks in the nanotechnology industry; Huan

Risk perception and risk communication on the issue of nanotechnology; Böl, Carreira, Epp, Häffner, and Lohmann

In vitro risk assessment of nanoparticles; Gaiser, Susewind, Ucciferri, Collnot, Ahluwalia, and Stone

Biological responses to nanoparticles; Zellner, Blechinger, Bräuchle, Hilger, Janshoff, Lademann, Mailänder, Meinke, Nienhaus, Patzelt, Rancan, Rothen-Rutishauser, Stauber, Torrano, Treuel, and Vogt

Cell and protein interactions with small-scale diamond materials; Narayan, Boehm, and Monteiro-Riviere

Intracellular transport and unpacking of polyplex nanoparticles; Rosenkranz, Khramtsov, Ulasov, Rodichenko, and Sobolev

Complement activation: a capricious immune barrier to nanomedicine clinical application; Szebeni

Nanotoxicology: Focus on nanomedicine; Johnston, Kermanizadeh, and Stone

Toxicity and genotoxicity of metal and metal oxide nanomaterials: a general introduction; Rey, Sanz, and Moya

Toxicity of silicon dioxide nanoparticles in mammalian neural cells; Lai, Jaiswal, Lai, Jandhyam, Leung, and Bhushan

Section IV – Future Implications, Ethics and Perspectives

Future concepts in nanomedicine; Burgess

Is translational medicine the future of therapy?; Milne and Mittra

Nanomedical cognitive enhancement: challenges and future possibilities; Swan

Nanomedicine: Ethical considerations; Kuiken

Clinical nanobioethical problems: a value approach; Álvarez-Díaz

Nanomedicine: shadow and substance; Farhangrazi and Moghimi

The Tower of Babel: miscommunication within and about nanomedicine; Juliano

Is nanotechnology toxic? Was Prince Charles correct?; Favi and Webster

The audience is the message: nanomedicine as apotheosis or damnatio memoriae;Berube

A Sample of Religious Thought on Nanotechnology; Toumey