Cellular and Molecular Neurophysiology

Key Features

# 80% new or updated material
# Fifteen appendices describing neurobiological techniques are interspersed in the text
# Now in full color throughout, with more than 400 carefully selected and constructed illustrations
# Provides an instructor website with all the images in electronic format, plus additional material
Related Titles

* Basic Neurochemistry, 7th Edition : Molecular, Cellular and Medical Aspects
* From Molecules to Networks : An Introduction to Cellular and Molecular Neuroscience
* Development of the Nervous System, 2nd Edition

Description

This third edition is the new, thoroughly revised edition of the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While the book does cover the important facts, it also presents the background for how researchers arrived at this knowledge to provide a context for the field. It teaches not only how excitable cells work in detail, but also how to construct and conduct intelligent research experiments. This book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike.
Readership

Neurophysiologists, neurobiologists, neurologists, as well as graduate-level courses on neurophysiology.
Contents

Part I – Neurons: Excitable and Secretory Cells that Establish Synapses. Chapter 1: Neurons Chapter 2: Neuron –Glial Cell Cooperation Chapter 3: Ionic Gradients, Membrane Potential and Ionic Currents Appendix 3.1: The active transport of ions by pumps and transporters maintain the unequal distribution of ions Appendix 3.2: The passive diffusion of ions through an open channel Appendix 3.3: The Nernst equation Chapter 4: The Voltage-Gated Channels of Na+ Action Potentials Appendix 4.1: Current clamp recording Appendix 4.2: Voltage clamp recording Chapter 5: The Voltage-Gated Channels of Ca+2Action Potentials: Generalization Appendix 5.1: Fluorescence measures of intracellular Ca2+ concentration Appendix 5.2: Tail currents Chapter 6: The Chemical Synapses Appendix 6.1: Neurotransmitters, agonists and antagonists Appendix 6.2: Identification and Localization of Neurotransmitters and their Receptors Chapter 7: Neurotransmitter Release Appendix 7.1: Quantal nature of neurotransmitter release Appendix 7.2: The probabilistic nature of neurotransmitter release (the neuromuscular junction as a model) Part 2 – Ionotropic and Metabotropic Receptors in Synaptic Transmission and Sensory Transduction. Chapter 8: The Ionotropic Nicotinic Acetycholine Receptors Appendix 8.1: The neuronal nicotinic receptors Chapter 9: The Ionotropic GABAA Receptor Appendix 9.1: Mean time and mean burst duration of the GABAA single-channel current Appendix 9.2: Non-invasive measurements of membrane potential and of the reversal potential of the GABAA current using cell-attached recordings of single channels Chapter 10: The Ionotropic Glutamate Receptors Chapter 11: The Metabotropic GABAB Receptors Chapter 12: The Metabotropic Glutamate Receptors Part 3 – Somato-Dendritic Processing and Plasticity of Postsynaptic Potentials. Chapter 13: Somato-Dendritic Processing of Postsynaptic Potentials I: Passive Properties of Dendrites Chapter 14: Subliminal Voltage-Gated Currents of the Somato-Dendritic Membrane Chapter 15: Somato-Dendritic Processing of Postsynaptic Potentials II: Role of Subliminal Depolarizing Voltage-Gated Currents Chapter 16: Somato-Dendritic Processing of Postsynaptic Potentials III: Role of High Voltage-Activated Depolarizing Currents Chapter 17: Firing Patterns of Neurons Chapter 18: Synaptic Plasticity Appendix 18.1: Depolarization of induced suppression of inhibition (DSI) Part 4 – The Adult Hippocampal Network. Chapter 19: The Adult Hippocampal network Chapter 20: Maturation of the Hippocampal Network

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