Atlas of Head and Neck Pathology

With its consistent, practical organization and succinct bulleted format, Atlas of Head and Neck Pathology, 4th Edition, is an ideal resource for pathologists in training and in practice. High-quality illustrations with extensive figure legends depict the histological, immunohistochemical, cytologic and diagnostic imaging appearances of every type of head and neck pathology, while the user-friendly format allows for quick access to information. From cover to cover, this comprehensive reference is designed to help you effectively and accurately diagnose a wide range of head and neck disorders, improve your turnaround time when diagnosing a specimen, and facilitate clear reports on prognosis and therapeutic management options to surgical and medical colleagues. 

• Instructions for online access

• Cover image

• Title page

• Table of Contents

• Dedication

• Copyright

• In Memoriam

• Preface

• Section 1. Nasal Cavity and Paranasal Sinuses

• Section 1. Nasal Cavity and Paranasal Sinuses

• Chapter 1. Embryology, Anatomy, and Histology of the Sinonasal Tract

• Nasal Cavity

• Paranasal Sinuses

• Chapter 2. Nonneoplastic Lesions of the Sinonasal Tract

• Classification of Nonneoplastic Lesions of the Sinonasal Tract (Box 2.1)

• Infectious-Related Diseases of the Sinonasal Tract

• Noninvasive FRS

• Invasive Fungal Sinusitis (Figs. 2.40 and 2.41)

• Other Fungi (Fig. 2.48)

• Bacterial Infections

• Miscellaneous Sinonasal Bacterial Infections

• Protozoal Nasal Infections

• Viral Infection

• Sarcoidosis

• Myospherulosis (Fig. 2.53)

• Extranodal Rosai-Dorfman Disease (ERDD) (Fig. 2.54)

• Granulomatosis With Polyangiitis (GPA) (Figs. 2.55–2.58)

• Eosinophilic Angiocentric Fibrosis (EAF) (Fig. 2.60)

• IgG4-Related Diseases

• Necrotizing Sialometaplasia (NS)

• Chapter 3. Neoplasms of the Sinonasal Tract

• Classification of Neoplasms of the Sinonasal Tract (Box 3.1)

• Benign Neoplasms

• Fibromatosis/Extraabdominal Fibromatoses

• Malignant Neoplasms of the Nasal Cavity and Paranasal Sinuses

• Rhabdomyosarcoma (RMS)

• Section 2. Oral Cavity

• Section 2. Oral Cavity

• Chapter 4. Embryology, Anatomy, and Histology of the Oral Cavity

• Embryology

• Contents (Fig. 4.1)

• Anatomic Borders

• Innervation

• Vascular Supply and Lymphatic Drainage

• Chapter 5. Nonneoplastic Lesions of the Oral Cavity

• Classification of Nonneoplastic Lesions of the Oral Cavity (Box 5.1)

• Cystic (Nonneoplastic) Lesions

• Infectious Diseases

• Reactive, Inflammatory, and Tumor-Like Lesions of the Oral Cavity

• Nonneoplastic Osseous-Related Lesions of the Head and Neck

• Selective Autoimmune, Allergic, Systemic, Cutaneous-Type, and Miscellaneous Diseases Affecting the Oral Cavity

• Chapter 6. Neoplasms of the Oral Cavity

• Benign Neoplasms

• Premalignant Oral Diseases/Lesions

• Chapter 7. Intraoperative Consultation in Oral Cavity Mucosal Lesions

• Indications

• Surgeon’s Expectations

• Specimen Handling and Orientation (Figs. 7.1 and 7.2)

• Right-Angle (Perpendicular) Versus Parallel (En Face) Sections

• Surgical Resection Margins

• Differential Diagnosis or Pitfalls in the Intraoperative Assessment of Squamous Cell Carcinoma, Including Intraepithelial Dysplasia and Invasive Carcinoma

• Contraindications (Fig. 7.11)

• Intraoperative “Rapid” Immunohistochemical Assessment

• Molecular Biology in the Assessment of Surgical Margins (Molecular Margins of Resection)

• Accuracy

• Lymph Nodes

• Section 3. Pharynx, Including Nasopharynx, Oropharynx, and Hypopharynx

• Section 3. Pharynx, Including Nasopharynx, Oropharynx, and Hypopharynx

• Chapter 8. Embryology, Anatomy, and Histology of the Pharynx

• Pharynx

• Histology

• Chapter 9. Nonneoplastic Lesions of the Pharynx

• Classification of Nonneoplastic Lesions of the Pharynx (Box 9.1)

• Nasopharyngeal Cysts

• Pharyngeal Hamartomas, Choristomas, and Teratomatous Lesions

• Infectious Diseases

• Viral Diseases

• Fungi

• Bacteria and Spirochetes

• Protozoa (Fig. 9.21)

• Tangier Disease (Fig. 9.22)

• Chapter 10. Neoplasms of the Pharynx

• Neoplasms of the Pharynx (Box 10.1)

• Malignant Tumors

• Section 4. The Neck

• Section 4. The Neck

• Chapter 11. Anatomy of the Neck

• Anatomy (Fig. 11.1)

• Chapter 12. Nonneoplastic Lesions of the Neck

• Classification of Nonneoplastic Lesions of the Neck (Box 12.1)

• Benign Cystic Lesions of the Cervical Neck

• Mycobacterial and Other Granulomatous Diseases

• Bacterial Diseases

• Chapter 13. Neoplasms of the Neck

• Classification of Neoplasms of the Neck (Box 13.1)

• Surgical Specimens

• Borderline or Intermediate Fibroblastic/Myofibroblastic Tumors

• Malignant Tumors

• Evaluation of Posttreated Neck for Metastatic Carcinoma (Fig. 13.60)

• Secondary Tumors to the Neck (Other Than Carcinoma From Head and Neck Sites)

• Section 5. Larynx and Trachea

• Section 5. Larynx and Trachea

• Chapter 14. Embryology, Anatomy, and Histology of the Larynx and Trachea

• Larynx

• Hypopharynx

• Trachea

• Chapter 15. Nonneoplastic Lesions of the Larynx and Trachea

• Classification of Nonneoplastic Lesions of the Larynx and Trachea (Box 15.1)

• Acquired and Congenital Lesions

• Laryngocele and Laryngeal Cysts

• Chapter 16. Neoplasms of the Larynx and Trachea

• Classification of NEOPLASMS of the Larynx and Trachea (Box 16.1)

• Benign Neoplasms of the Larynx

• Benign Salivary Gland Tumors

• Benign Nonepithelial Tumors

• Malignant Neoplasms

• Laryngeal Intraepithelial Dysplasia

• Laryngeal Carcinoma In Situ (CIS) (Fig. 16.22)

• Microinvasive Carcinoma (Figs. 16.23–16.26)

• Laryngeal Invasive Squamous Cell Carcinoma (Figs. 16.27–16.31)

• Variants of Squamous Cell Carcinoma (Box 16.4)

• Other Uncommon Carcinoma Variants

• Laryngeal Salivary Gland Malignant Neoplasms

• Laryngeal Neuroendocrine Neoplasms

• Laryngeal Neuroendocrine Neoplasms (See Box 16.5)

• Laryngeal Neuroendocrine Carcinomas

• Nonepithelial Malignant Neoplasms of the Larynx

• Chapter 17. Intraoperative Consultation of Laryngeal and Tracheal Lesions

• Indications

• Surgeon Expectations

• Specimen Handling and Orientation

• Definition of a “Positive” Margin

• Adequacy of Resection Margins

• Section 6. Major and Minor Salivary Glands

• Section 6. Major and Minor Salivary Glands

• Chapter 18. Embryology, Anatomy, and Histology of the Salivary Glands

• Embryology

• Anatomic Borders (Fig. 18.1)

• Innervation

• Histology (Figs. 18.2–18.5; Tables 18.1 and 18.2)

• Chapter 19. Nonneoplastic Diseases of Salivary Glands

• Classification of Nonneoplastic Salivary Gland Lesions (Box 19.1)

• Developmental Lesions

• Hyperplasia and Metaplasia

• True Nonneoplastic Cysts of Major Salivary Glands (Sialocysts)

• Nondevelopmental Cysts

• Infectious, Inflammatory, Autoimmune Lesions of Salivary Glands

• Chapter 20. Neoplasms of the Salivary Glands

• Classification of Neoplasms of Salivary Glands (Box 20.1)

• Benign Neoplasms

• Basal Cell Adenoma (BCA)(Figs. 20.19–20.25)

• Warthin Tumor (WT) (Figs. 20.26–20.32)

• Canalicular Adenoma (CA)(Figs. 20.33–20.35)

• Oncocytoma (Fig. 20.36)

• Myoepithelioma (Figs. 20.37–20.41)

• Cystadenoma (Fig. 20.42)

• Ductal Papillomas

• Other Uncommon Benign Epithelial Neoplasms

• Tumors With Sebaceous Differentiation

• Benign Soft Tissue Tumors

• Malignant Neoplasms

• Polymorphous Adenocarcinoma Classification—Genotypic-Phenotypic Correlation

• Malignant Mixed Tumors of Salivary Glands

• Cystadenocarcinoma (Figs. 20.145–20.148)

• Microsecretory Adenocarcinoma (Figs. 20.149 and 20.150)

• Sclerosing Microcystic Adenocarcinoma (Fig. 20.151)

• Mucinous Adenocarcinoma (Fig. 20.152)

• Adenocarcinoma, Not Otherwise Specified (Figs. 20.153–20.157)

• Primary Squamous Cell Carcinoma (SCC) (Figs. 20.158 and 20.159)

• Lymphoepithelial Carcinoma (LEC) (Figs. 20.160 and 20.161)

• Neuroendocrine Neoplasms

• Malignant Sebaceous Tumors

• Nonepithelial Malignant Salivary Gland Tumors

• Sarcomas of Salivary Glands

• Secondary Tumors

• Chapter 21. Intraoperative Consultation in Salivary Glands and Biopsy Diagnosis of Salivary Gland Neoplasms

• Intraoperative Consultation in Salivary Glands (Figs. 21.1–21.13)

• Indications for Intraoperative Consultation in Salivary Gland Neoplasms

• Surgeon’s Expectations of the Intraoperative Assessment of Salivary Gland Neoplasms

• Approach to Handling of Resected Tissue

• Diagnostic Considerations

• Accuracy of Intraoperative Diagnosis

• Biopsy Diagnosis of Salivary Gland Neoplasms (Figs. 21.14 to 21.19)

• CONCLUSIONS

• Section 7. External, Middle, and Internal Ear

• Section 7. External, Middle, and Internal Ear

• Chapter 22. Embryology, Anatomy, and Histology of the Ear

• Embryology

• Anatomy (Figs. 22.1 to 22.3)

• Eustachian (Auditory) Tube

• Innervation

• Blood Supply and Lymphatic Drainage

• Histology (Fig. 22.4)

• Auditory Epithelial Migration

• Middle Ear (Figs. 22.5 and 22.6)

• Chapter 23. Nonneoplastic Lesions of the Ear and Temporal Bone

• Classification of Nonneoplastic Lesions of the Ear (Box 23.1)

• Congenital and Developmental Abnormalities of the Ear

• External Ear

• Middle and Inner Ear

• Heterotopias (Choristomas) of the Middle Ear and Mastoid

• Acquired Lesions of the Ear

• Middle Ear and Temporal Bone

• Infectious and Inflammatory Lesions

• Otitis Media (Figs. 23.24 to 23.27)

• Autoimmune, Systemic, and Degenerative Diseases of the Ear

• Tophaceous Gout (Figs. 23.34 and 23.35)

• Granulomatosis With Polyangiitis (GPA) (See Chapter 2)

• Otosclerosis (Fig. 23.38)

• Paget Disease of Bone (Figs. 23.39 and 23.40)

• Ménière Disease

• Chapter 24. Neoplasms of the Ear and Temporal Bone

• Classification of Neoplasms of the Ear (Box 24.1)

• Benign Neoplasms of the Middle Ear and Temporal Bone

• Malignant Neoplasms of the External Ear

• Malignant Neoplasms of the Middle Ear

• Other Malignant Tumors of the Middle Ear and Temporal Bone

• Chapter 25. Immunohistochemistry of Middle Ear Neoplasms

• Section 8. Thyroid Gland

• Section 8. Thyroid Gland

• Chapter 26. Embryology, Anatomy, Histology, and Physiology of the Thyroid Gland

• Embryology (Fig. 26.1)

• Anatomy (Fig. 26.2)

• Vascular Supply and Lymphatics

• Histology

• Thyroid C Cells (Fig. 26.6)

• Chapter 27. Nonneoplastic Lesions of the Thyroid Gland

• Classification of Nonneoplastic Lesions of the Thyroid Gland ( Box 27.1)

• Ovarian Thyroid Tissue (Figs. 27.16–27.18)

• Metaplasia of Thyroid Follicular Epithelium

• Mesenchymal-Derived “Inclusions” in the Thyroid Gland

• Hypothyroidism and Hyperthyroidism

• Nonautoimmune Thyroiditis

• Chapter 28. Neoplasms of the Thyroid Gland

• CLASSIFICATION OF NEOPLASMS OF THE THYROID GLAND (BOX 28.1)

• MOLECULAR GENETICS OF FOLLICULAR CELL–DERIVED THYROID TUMORS (TABLE 28.7)

• MOLECULAR DICHOTOMY

• CLINICAL STAGING OF THYROID CARCINOMA

• Benign Follicular Epithelial Neoplasms

• HISTOLOGIC TYPES OF FOLLICULAR THYROID ADENOMA CLASSIFIED BY CELL TYPE OR GROWTH PATTERN (BOX 28.3)

• LOW-RISK FOLLICULAR CELL–DERIVED NEOPLASMS

• NONINVASIVE FOLLICULAR THYROID NEOPLASM WITH PAPILLARY-LIKE NUCLEAR FEATURES (NIFTP) (FIGS. 28.24–28.28)

• MALIGNANT FOLLICULAR EPITHELIAL AND C CELL–DERIVED NEOPLASMS

• PAPILLARY THYROID CARCINOMA (PTC)

• HISTOLOGIC TYPES OF PTC (BOX 28.6)

• FOLLICULAR VARIANT OF PAPILLARY THYROID CARCINOMA (FVPTC)

• HIGH-GRADE FOLLICULAR CELL–DERIVED NONANAPLASTIC THYROID CARCINOMAS

• UNUSUAL EPITHELIAL TUMORS OF THE THYROID GLAND

• Neuroendocrine Neoplasms

• C CELL–RELATED LESIONS (C CELL HYPERPLASIA AND MEDULLARY THYROID CARCINOMA)

• Lymphoproliferative Diseases of the Thyroid Gland

• MALIGNANT LYMPHOPROLIFERATIVE NEOPLASMS

• Nonepithelial Neoplasms of the Thyroid, Excluding Lymphoproliferative Diseases

• THYROID LESIONS WITH THYMIC DIFFERENTIATION

• INTRATHYROID THYMIC CARCINOMA OR CARCINOMA SHOWING THYMUS-LIKE DIFFERENTIATION (CASTLE) (FIG. 28.130)

• SECONDARY OR METASTATIC TUMORS TO THE THYROID GLAND (FIGS. 28.132–28.134)

• Chapter 29. Thyroid Gland Post–Fine Needle Aspiration Biopsy–Related Histologic Changes and Intraoperative Consultation

• Post–Fine Needle Aspiration Biopsy (FNAB)–Related Morphologic Changes (Figs. 29.1–29.12)

• Surgeon’s Expectations

• Intraoperative Cytology

• Summary

• Section 9. Parathyroid Glands

• Section 9. Parathyroid Glands

• Chapter 30. Embryology, Anatomy, and Histology of the Parathyroid Glands

• Embryology

• Anatomic Considerations (Fig. 30.1)

• Histology (Figs. 30.2–30.4; Table 30.1)

• Chapter 31. General Considerations

• Hyperparathyroidism

• Hypoparathyroidism

• Chapter 32. Nonneoplastic Lesions of the Parathyroid Glands

• Classification of Nonneoplastic Lesions of the Parathyroid Glands (Box 32.1)

• Primary Chief Cell Hyperplasia (Figs. 32.1–32.5; Table 32.1)

• Water–Clear-Cell Hyperplasia (Fig. 32.6)

• Secondary Hyperparathyroidism

• Tertiary Hyperparathyroidism

• Parathyromatosis (Fig. 32.8)

• Parathyroid Cyst (Figs. 32.9–32.11)

• Chronic Parathyroiditis (Fig. 32.12)

• Chapter 33. Neoplasms of the Parathyroid Glands

• Classification of Neoplasms of the Parathyroid Glands (Box 33.1)

• Chapter 34. Intraoperative Consultation (Frozen Section) in Parathyroid Gland and Parathyroid Proliferative Disease/Hyperparathyroidism

• Considerations

• Normal Size and Weight (Table 34.1)

• Indications for Intraoperative Consultation for Hyperparathyroidism

• Surgeons’ Expectations of the Intraoperative Assessment of Parathyroid Exploration

• Practical Reality of the Intraoperative Assessment of Parathyroid Exploration

• Handling of Resected Parathyroid Glands

• Inking of Parathyroid Glands

• Microscopic Findings on Frozen Section

• Microhyperplasia

• FlowChart for Intraoperative Assessment for Hyperparathyroidism

• Pitfalls and/or Issues in the Intraoperative Evaluation of Parathyroid Glands

• Reexploration for Persistent or Recurrent Hyperparathyroidism

• Parathyroid Carcinoma

• Parathyroid Proliferative Disease in “Ectopic” Sites

• Adjunct Methods in the Intraoperative Evaluation of PPD

• Intraoperative Monitoring of Parathyroid Hormone Levels

• Accuracy of Intraoperative Confirmation of Parathyroid Tissue and Intraoperative Diagnosis

• Section 10. Multiple Endocrine Neoplasia (MEN) Syndromes

• Section 10. Multiple Endocrine Neoplasia (MEN) Syndromes

• Chapter 35. Multiple Endocrine Neoplasia Syndromes and Selective Inherited Syndromes With Associated Endocrine Neoplasms

• MEN Type 1

• MEN Type 2

• Familial Medullary Thyroid Carcinoma (FMTC)

• MEN Type 4

• MEN 5 (MAX-Related Tumors)

• Selective Inherited Syndromes With Different Endocrine Neoplasms

• Index

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